TY  - BOOK
AU  - Casavant,Sharon G.
AU  - Chen,Jie
AU  - Xu,Wanli
AU  - Lainwala,Shabnam
AU  - Matson,Adam
AU  - Chen,Ming-Hui
AU  - Starkweather,Angela
AU  - Maas,Kendra
AU  - Cong,Xiaomei S.
TI  - Multi-omics analysis on neurodevelopment in preterm neonates : : a protocol paper
PY  - 2021///
KW  - Age Factors
KW  - Child, Preschool
KW  - Disease
KW  - Gastrointestinal Microbiome
KW  - Gestational age
KW  - Growth and Development - genetics
KW  - Growth and Development - physiology
KW  - Health Status
KW  - Infant, Newborn - growth & development
KW  - Infant, Premature - growth & development
KW  - Longitudinal study
KW  - Medicine
KW  - Multi omics
KW  - Necrotizing enterocolitis
KW  - Neonatal intensive care unit
KW  - Neurodevelopmental Disorders - diagnosis
KW  - Pediatrics
N2  - Background 

The gut microbiome is an important determinant of health and disease in preterm infants.
Objectives 

The objective of this article was to share our current protocol for other neonatal intensive care units to potentially expand their existing protocols, aiming to characterize the relationship between the intestinal microbiome and health outcomes in preterm infants.
Methods 

This prospective, longitudinal study planned to recruit 160 preterm infants born <32 weeks gestational age or weighing <1,500 g and admitted to one of two Level III/IV neonatal intensive care units. During the neonatal intensive care unit period, the primary measures included events of early life pain/stress, gut microbiome, host genetic variations, and neurobehavioral assessment. During follow-up visits, gut microbiome; pain sensitivity; and medical, growth, and developmental outcomes at 4, 8–12, and 18–24 months corrected age were measured.
Discussion 

As of February 14, 2020, 214 preterm infants have been recruited. We hypothesize that infants who experience greater levels of pain/stress will have altered gut microbiome, including potential adverse outcomes such as necrotizing enterocolitis and host genetic variations, feeding intolerance, and/or neurodevelopmental impairments. These will differ from the intestinal microbiome of preterm infants who do not develop these adverse outcomes. To test this hypothesis, we will determine how alterations in the intestinal microbiome affect the risk of developing necrotizing enterocolitis, feeding intolerance, and neurodevelopmental impairments in preterm infants. In addition, we will examine the interaction between the intestinal microbiome and host genetics in the regulation of intestinal health and neurodevelopmental outcomes

ER  -